For a lot of human historical past, individuals received their medication from nature. Marijuana comes from the hashish plant, cocaine from coca leaves, heroin from poppies and magic mushrooms actually do come from mushrooms. Even authorized medication, like alcohol, tobacco and occasional, come from crops. Their highs have been usually found by probability, when somebody consumed them in simply the fitting means.

However in as we speak’s overdose disaster, probably the most damaging medication don’t come from crops. They’re artificial — manufactured in a lab, often requiring no crops in any respect.

Final 12 months, fentanyl — an artificial opioid — brought on extra overdose deaths than another drug has in a single 12 months. The second-deadliest drug was meth, which can be produced in labs (the sort you may need seen in “Breaking Dangerous”).

Collectively, fentanyl and meth helped make 2021 the worst 12 months for drug overdoses in U.S. historical past: The complete-year dying toll topped 100,000 for the primary time, the C.D.C. reported final week.

Each medication have proliferated so shortly as a result of they’re artificial.

Traffickers choose synthetics as a result of they will make and ship the medication world wide extra shortly and discreetly. Cartels now not want a big, uncovered discipline with dozens of employees to mass-produce medication; they will simply begin a lab in a tucked-away warehouse or house constructing with a handful of chemists. And these technicians could make extra highly effective medication, which lets traffickers smuggle smaller quantities for a similar excessive.

Drug customers usually choose synthetics, too: The medication are usually cheaper, despite the fact that they’re stronger.

So fentanyl and meth have unfold seemingly all over the place, pushing overdose deaths to report highs 12 months after 12 months.

America’s antidrug efforts have struggled to maintain up with the rise in synthetics, letting the overdose disaster worsen.

In some methods, the medication’ rise is the most recent flip in an escalating competitors between regulation enforcement and traffickers. Smugglers hid medication in cargo in automobiles, boats and planes, so the authorities deployed drug-sniffing canines and carried out extra thorough stops and searches. Traffickers flew medication throughout the border with drones, so regulation enforcement launched blimps with low-altitude radar to detect them.

However artificial medication are a serious shift in that battle. Regina LaBelle, the previous appearing drug czar for President Biden, instructed me their rise was her workplace’s “worst nightmare.” The normal battle on medication largely targeted on stopping the move of medicine grown on farms. It didn’t work completely, nevertheless it had a major impact: One professional estimated that prohibition elevated the value of heroin and cocaine by 10 to twenty instances, so customers have been much less doubtless, or ready, to purchase them.

The impression is probably going smaller for artificial medication as a result of they’re simpler to make and smuggle.

With synthetics, the authorities might not even know what to search for. New artificial medication recurrently pop up — usually with impossible-sounding names, like “isotonitazene” — making it arduous for officers to maintain up with the most recent risk.

Many specialists now argue that the U.S. must battle the habit disaster by investing in various methods that focus extra on increasing therapy and on harm reduction than on lowering the availability of medicine. On the fee that overdose deaths are rising, the alternate options stands out as the solely choice.

For extra: Drug customers are mixing opioids and stimulants in additional harmful combos generally known as “speedballs” and “goofballs.”

A Occasions traditional: Do this 20-minute exercise anyplace.

Recommendation from Wirecutter: Bike storage tips.

Lives Lived: Donald Okay. Ross was one of many authentic Nader’s Raiders, the regulation college students Ralph Nader mustered within the Nineteen Seventies to problem authorities and company forms. Ross promoted well being care, voting rights, tax reform and different points. He died at 78.

The N.B.A. playoffs are right down to 4 groups — Boston vs. Miami within the East, and Golden State vs. Dallas within the West. Right here’s one attention-grabbing participant to know from every crew:

Marcus Sensible, Celtics: The Celtics had among the best defenses within the N.B.A. this 12 months, thanks partially to Sensible. He was named the league’s greatest defensive participant — the primary time the award has gone to a guard for the reason that Nineties. Look ahead to his maniacal vitality. And you’ll’t miss his hair, dyed Celtics green.

Victor Oladipo, Warmth: The Warmth’s starters are nice, however the bench is sort of good, too, together with Oladipo, who was an all-star only some years in the past earlier than an damage paused his profession (and let him spend a season on The Masked Singer).

Klay Thompson, Warriors: Thompson helped take the Warriors to 5 Finals in a row. However he misplaced a season to a knee damage, after which an damage to his Achilles’ tendon price him one other. Now he’s again, lastly, nailing three-point photographs and commuting to games on his boat.

Luka Doncic, Mavericks: Doncic, the Mavericks’ wunderkind, isn’t a one-man crew. However he’s not so removed from it, both: He leads his crew in factors, rebounds and assists. In a single recreation over the past spherical of the playoffs, the opposing Phoenix Suns scored 27 factors within the first half; Doncic, on his personal, also scored 27.

The pangram from yesterday’s Spelling Bee was juvenile. Right here is as we speak’s puzzle — or you’ll be able to play online.

Right here’s today’s Wordle. Right here’s today’s Mini Crossword, and a clue: Uno + dos (4 letters).

In the event you’re within the temper to play extra, discover all our games here.

Thanks for spending a part of your morning with The Occasions. See you tomorrow.

P.S. “Elon Musk’s Crash Course,” a Occasions documentary about Tesla’s pursuit of a self-driving automotive, premieres tonight at 10 p.m.